Indian Journal of Pathology: Research and Practice

Fibrolipoma is one of the variants of lipoma which shows neoplastic adipocytes embedded within dense collagen. Its occurrence in the oral cavity is very rare and only few cases have been reported in the oral cavity. In this article, we are reporting a case of fibrolipoma involving upper alveolus in a 70 year old male patient. 

Keywords: Fibrolipoma; Lipoma. 

Synchronous multifocal/multicentric osteosarcoma (SMOS) is a rare variant of osteosarcoma with fewer than 100 well-documented cases in the medical literature. SMOS affecting the jaw is even rarer with only three cases involving the mandible reefing been reported. We report here a case of a 16-year-old mentally challenged girl with SMOS. Radiological examinations showed sclerotic lesions in the left distal femur and in right mandible without pulmonary metastasis. Histological examination showed osteoblastic- ype osteosarcoma with chondroid differentiation. Despite high-dose chemotherapy the patient died after 6 months after the initial diagnosis. Immunohistochemistry revealed that p53 protein was positive in most of the tumor cells. The clinical course, radiological and histological appearance of the lesion indicated it was an SMOS rather than metastasis arising from a single osteosarcoma. This case could be regarded as powerful evidence to support the multicentric theory related to SMOS. 

Keywords: Synchronous; Multifocal; Multicentric osteosarcoma. 

Clemens Peter Freiherr[1] von Pirquet (May 12, 1874 – February 28, 1929) was an Austrian scientist and pediatrician best known for his contributions to the fields of bacteriology and immunology. Born in Vienna, he studied theology at the University of Innsbruck and philosophy at the University of Leuven before he enrolled at the University of Graz where he became a doctor of medicine in 1900. He started practicing at the Children’s Clinic in Vienna. 

Keywords: Bacteriology; Immunology; Clemens Von Pirquet. 

Background: Dyslipidemia and oxidative stress were shown to be pathogenetic mechanisms for developing diabetic peripheral neuropathy (DPN), which could be influenced, prevented, controlled or managed through dietary or nutritional interventions.Objective: To explore the evidence for pathological basis of diet and nutrition (DAN) in pathogenesis and treatment of DPN. Methods: A systematic review was performed using search terms ‘diabetic neuropathy’ with filters activated for subject category of ‘Dietary Supplements’ combined with another advanced search strategy including title terms “diet and nutrition” in PubMed, CINAHL and Google Scholar to identify studies published in English, with abstracts. The search was independently performed by two testers and consensus was adopted to solve disagreements in presence of third tester. A three-level scrutiny of obtained citations was done to identify relevant studies and descriptive synthesis was done to organize studies under bench and bedside evidence. Results: There were a total 15 bench studies and three bedside studies that provided evidence for DAN in DPN. Amongst the 15 bench studies on experimental DPN in rats, high fat diet (two studies) and fructose-rich diet (one study) had pathogenetic effect, while fish oil, E. officinalis fruit extract, glutathione, resveratrol, olive leaf extract, naringin, gastrodin, soy isoflavone genistein, and coenzyme Q10 (one study each) and cucumin (three studies) had therapeutic effect. There were no pathogenetic studies on humans and three bedside therapeutic studies were one each on Linolenic acid, Alpha-Lipoic acid and cannabis. Conclusion: There was limited bedside evidence from few studies which warrant future high quality clinical trials on efficacy of alpha lipoic acid, linolenic acid and cannabis-based extract in the management of DPN. The bench evidence had shown that fat-rich and fructose-rich diets had pathogenetic effects and cucumin had therapeutic effects on experimentally induced DPN in rats. 

Keywords: Neuropathology; Neuropathogenesis; Pathogenetic neurorehabilitation; Neurometabolic syndrome; Diet and nutrition.