Home > Journals > Indian Journal of Genetics and Molecular Research

Indian Journal of Genetics and Molecular Research

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Sperm Chromatin Structure Assay in Oligospermic Infertile Men

More Kavita* , More Kavita* , Badade Z. G.* , Reeta Dhar** , Mukherjee S.*** Pandurang Thatkar****

Author Information

Licence:



Indian Journal of Genetics and Molecular Research 4(1):p 7-10, Jan-Jun 2015. | DOI: DOI: https://dx.doi.org/10.21088/ijgmr.2319.4782.4115.2

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

 Impairment of spermatogenesis and defective sperm function is the most prevalent cause of male infertility. Recent reports indicate that increasing male infertility could be due to genomic abnormalities. Therefore the present study was aimed to evaluate sperm DNA fragmentation in oligospermic infertile as well as fertile men and to study correlation of sperm DNA fragmentation with sperm parameters. The study is prospective, comprises 30 oligospermic infertile men and 30 fertile men. Sperm DNA integrity in terms of DNA fragmentation Index (DFI) was assessed by flow cytometer. Sperm DNA fragmentation was found to be significantly increased in oligospermic infertile men as compared to fertile men.  It was negatively correlated with sperm count and sperm motility. Therefore assessment of sperm DNA damage can be used to identify cause of infertility in patients with poor semen quality. This needs to be considered while treating patients with sperm quality anomalies for better outcomes of infertile patients.

Keywords: Sperm Chromatin Structure Assay (SCSA); DNA Fragmentation Index (DFI),  Oligospermia.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: https://dx.doi.org/10.21088/ijgmr.2319.4782.4115.2

Keywords


Article Level Metrics

Last Updated

Monday 22 June 2026, 00:07:46 (IST)

941

Accesses

2
274
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share