Full Text (PDF)
Original Article

Role of Application of Topical Nitroglycerine in Management of Flap Surgery

Ravi Kumar Chittoria, Nishad K null, Neljo Thomas, Barath Kumar Singh

Author Information

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.



Indian Journal of Preventive Medicine 11(1):p 23-25, January – June 2023. | DOI: 10.21088/ijpm.2321.5917.11123.2

How Cite This Article:

Nishad K, Thomas N, Chittoria RK, et al. Role of application of topical nitroglycerine in management of flap surgery. Indian J Prev Med. 2023;11(1):23-5.

Timeline

Received : December 13, 2022         Accepted : January 15, 2023          Published : February 28, 2023

Abstract

Flaps have been used for a long time for closure of soft tissue defects by plastic surgeons and form an important part of the surgeon’s armoury, however 2% −22% of flap procedures led to necrosis in an observational study.1 The search for an ideal intervention for ensuring flap survival still continues. Topical nitroglycerine has been found effective in prevention of flap necrosis in few studies.2-4 In this article we share our experience with prevention of flap necrosis using topical nitroglycerine.


References

  • 1.   Matsen CB, Mehrara B, Eaton A, et al. Skin flap necrosis after mastectomy with reconstruction: a prospective study. Ann Surg Oncol. 2016;23(1):257–64.
  • 2.   Gdalevitch P, Van Laeken N, Bahng S, et al. Effects of nitroglycerin ointment on mastectomy flap necrosis in immediate breast reconstruction: a randomized controlled trial. Plast Reconstr Surg. 2015;135(6):1530–9.
  • 3.   Rohrich RJ, Cherry GW, Spira M. Enhancement of skin flap survival using nitroglycerin ointment. Plast Reconstr Surg. 1984;73(6):943–8.
  • 4.   Yun MH, Yoon ES, Lee BI, Park SH. The effect of low-dose nitroglycerin ointment on skin flap necrosis in breast reconstruction after skin-sparing or nipple-sparing mastectomy. Arch Plast Surg. 2017;44(6):509–15.
  • 5.   Vargas CR, Iorio ML, Lee BT. A systematic review of topical vasodilators for the treatment of intraoperative vasospasm in reconstructive microsurgery. Plast Reconstr Surg. 2015;136(2):411–22.
  • 6.   Levin RI, Jaffe EA, Weksler BB, Tack-Goldman K. Nitroglycerin stimulates synthesis of prostacyclin by cultured human endothelial cells. J Clin Invest. 1981;67(3):762–9.
  • 7.   Scheuer S, Hanna MK. Effect of nitroglycerin ointment on penile skin flap survival in hypospadias repair: experimental and clinical studies. Urology. 1986;27(5):438–40.
  • 8.   Aral M, Tuncer S, Sencan A, Elmas C, Ayhan S. The effect of thrombolytic, anticoagulant, and vasodilator agents on the survival of random pattern skin flap. J Reconstr Microsurg. 2015;31(7):487–92.
  • 9.   De Sá JZ, de Aguiar JL, Cruz AF, Schuler AR, de Lima JR, Marques OM. Efeitos da nitroglicerina tópica na autonomização de retalhos pré-fabricados por implante vascular em ratos [Effects of topical nitroglycerin on the autonomization of vascular implant prefabricated flaps in rats]. Acta Cir Bras. 2012;27(12):905–11.
  • 10.   Dunn GL, Brodland DG, Griego RD, Huether MJ, Fazio MJ, Zitelli JA. A single postoperative application of nitroglycerin ointment does not increase survival of cutaneous flaps and grafts. Dermatol Surg. 2000;26(5):425–7.

About this article


Cite this article

Nishad K, Thomas N, Chittoria RK, et al. Role of application of topical nitroglycerine in management of flap surgery. Indian J Prev Med. 2023;11(1):23-5.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.



Received Accepted Published
December 13, 2022 January 15, 2023 February 28, 2023

DOI: 10.21088/ijpm.2321.5917.11123.2

Keywords

Topical nitroglycerineFlap necrosis

Article Level Metrics

Last Updated

Wednesday 17 June 2026, 20:24:29 (IST)


571

Accesses

6
144
00

Citations


NA
NA
NA

Download citation


Article Keywords


Keyword Highlighting

Highlight selected keywords in the article text.


Timeline


Received December 13, 2022
Accepted January 15, 2023
Published February 28, 2023

licence


Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.



Access this article



Share