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Indian Journal of Preventive Medicine 13(1):p 27-31, Jan-June 2025. | DOI: https://doi.org/10.21088/ijpm.2321.5917.13125.5
Case Report
Primary Systemic Amyloidosis of Stomach and Duodenum: A Rare Case Report
Upendra Baitha, Sarada Priyadarshini Suna, Anand Rajendran, Shikhar Gupta, Paras Singla, Amandeep Singh, Gaurav Gupta
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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Indian Journal of Preventive Medicine 13(1):p 27-31, Jan-June 2025. | DOI: https://doi.org/10.21088/ijpm.2321.5917.13125.5
How Cite This Article:
Sarada Priyadarshini Suna, Anand Rajendran, Shikhar Gupta, et al. Primary Systemic Amyloidosis of Stomach and Duodenum: A Rare Case Report. J Prev Med. 2025; 13(1): 27-31.Timeline
Received : February 06, 2025
Accepted : June 10, 2025
Published : June 30, 2025
Abstract
Primary amyloidosis is a group of monoclonal plasma cell disorders characterized by the extracellular deposition of immunoglobulin light chain fibrils in multiple organs, leading to progressive multi-organ dysfunction. It is a rare disease that usually occurs in elderly persons and has a poor prognosis. Primary amyloidosis of the gastrointestinal tract is relatively rare, and symptomatic amyloidosis of the stomach is even more seldom. Monoclonal gammopathy often undervalues nephropathy, a rare condition of renal significance. We present the case of a 28-year-old female who presented with recurrent vomiting, abdominal distension, poor oral intake, and weight loss for two months. Her upper GI endoscopy was done, which showed edematous nodular antral mucosa and superficial ulcers in the third part of the duodenum. Biopsies were taken, which showed features suggestive of primary amyloidosis with kappa light chain restriction. A renal biopsy revealed that she had a lot of damage to her tubes, including an unusual intratubular cast with kappa light chain restriction. People often underestimate monoclonal gammopathy of renal significance (MGRS), a rare condition.
References
- 1. Bhat A., Selmi C., Naguwa S.M., Cheema G.S., Gershwin M.E. Current concepts on the immunopathology of amyloidosis. Clin Rev Allergy Immunol. 2010 Apr; 38: 97-106. doi:10.1007/s12016-009-8163-9. PMID: 19626465.
- 2. Harsh Mohan. Immunopathology including amyloidosis. Text Book of Pathology, 5th ed. Jaypee brothers; 2005: 83-92.
- 3. Gertz M.A., Lacy M.Q., Dispenzieri A. Amyloidosis: recognition, confirmation, prognosis, and therapy. Mayo Clin Proc. 1999 May; 74: 490-4. doi:10.4065/74.5.490. PMID: 10319082.
- 4. Menke D.M., Kyle R.A., Fleming C.R., Wolfe J.T. 3rd, Kurtin P.J., Oldenburg WA. Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis. Mayo Clin Proc. 1993 Aug; 68: 763-7. doi:10.1016/s0025- 6196(12)60634-x. PMID: 8331978.
- 5. Rivera R., Kaul V., DeCross A., Whitney-Miller C. Primary gastric amyloidosis presenting as an isolated gastric mass. Gastrointest Endosc. 2012 Jul; 76: 186-7. doi:10.1016/j.gie.2012.02.059. PMID: 22726480.
- 6. Björnsson S., Jóhannsson J.H., Sigurjónsson F. Localized primary amyloidosis of the stomach presenting with gastric hemorrhage. Acta Med Scand. 1987; 221: 115-9. doi:10.1111/j.0954-6820.1987.tb01252.x.PMID: 3494384.
- 7. Sawada T., Adachi Y., Akino K., et al. Endoscopic features of primary amyloidosis of the stomach. Endoscopy. 2012; 44 Suppl 2 UCTN: E275-6. doi:10.1055/s-0032-1309750. Epub 2012 Jul 13. PMID: 22814919.
- 8. Leung N., Bridoux F., Hutchison C.A., et al. Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood. 2012 Nov 22; 120: 4292-5. doi:10.1182/blood-2012-07-445304. Epub 2012 Oct 9. PMID: 23047823.
- 9. Merlini G., Stone M.J. Dangerous small B-cell clones. Blood. 2006 Oct 15; 108: 2520-30. doi:10.1182/blood-2006-03-001164. Epub 2006 Jun 22. PMID: 16794250.
- 10. Desport, E., Bridoux, F., Sirac, C., et al. A.L. Amyloidosis. Orphanet J Rare Dis 7, 54 (2012).
- 11. Saoji V., Chaudhari S., Gohokar D. Primary systemic amyloidosis: three different presentations. Indian J Dermatol Venereol Leprol. 2009 Jul-Aug; 75: 394-7. doi:10.4103/0378-6323.53138. PMID: 19584467.
- 12. Ciocchini M., Arbelbide J., Musso C.G. Monoclonal gammopathy of renal significance (MGRS): The characteristics and significance of a new meta-entity. Int Urol Nephrol. 2017 Dec; 49: 2171-2175. doi:10.1007/s11255-017-1594-y. Epub 2017 Apr 19. PMID: 28425076.
- 13. Sethi S., Fervenza F.C., Rajkumar S.V. Spectrum of manifestations of monoclonal gammopathyassociated renal lesions. Curr Opin Nephrol Hypertens. 2016 Mar; 25: 127-37. doi:10.1097/MNH.0000000000000201. PMID: 26735145.
- 14. Bridoux F., Leung N., Hutchison C.A., et al. Diagnosis of monoclonal gammopathy of renal significance. Kidney Int. 2015 Apr;87:698-711. doi:10.1038/ki.2014.408. Epub 2015 Jan 21. PMID: 25607108.
- 15. Rajkumar S.V., Dispenzieri A., Kyle R.A. Monoclonal gammopathy of undetermined significance, Waldenström macroglobulinemia, A.L. amyloidosis, and related plasma cell disorders: diagnosis and treatment. Mayo Clin Proc. 2006 May; 81: 693-703. doi:10.4065/81.5.693. Erratum in: Mayo Clin Proc. 2006 Nov;81(11):1509. PMID: 16706268.
- 16. Rosenzweig M., Landau H. Light chain (AL) amyloidosis: update on diagnosis and management. J Hematol Oncol. 2011 Nov 18; 4: 47. doi:10.1186/1756-8722-4-47. PMID: 22100031; PMCID: PMC3228694.
- 17. Gertz M.A., Lacy M.Q., Dispenzieri A., et al. Autologous stem cell transplant for immunoglobulin light chain amyloidosis: a status report. Leuk Lymphoma. 2010 Dec; 51: 2181-7. doi:10.3109/10428194.2010.524329. Epub 2010 Oct 20. PMID: 20958232.
- 18. Fermand J.P., Bridoux F., Kyle R.A., et al.How I treat monoclonal gammopathy of renal significance (MGRS). Blood. 2013 Nov 21; 122: 3583-90. doi:10.1182/blood-2013-05-495929. Epub 2013 Oct 9. PMID: 24108460.
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
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This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
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Cite this article
Sarada Priyadarshini Suna, Anand Rajendran, Shikhar Gupta, et al. Primary Systemic Amyloidosis of Stomach and Duodenum: A Rare Case Report. J Prev Med. 2025; 13(1): 27-31.
Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
| Received | Accepted | Published |
|---|---|---|
| February 06, 2025 | June 10, 2025 | June 30, 2025 |
DOI: https://doi.org/10.21088/ijpm.2321.5917.13125.5
Keywords
Primary Systemic AmyloidosisGastrointestinal tractMGRSCardiacLight chainArticle Level Metrics
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Timeline
| Received | February 06, 2025 |
| Accepted | June 10, 2025 |
| Published | June 30, 2025 |
licence
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
