Abstract

Background: Early identification of sepsis is essential as the mother has risk of chorioamnionitis. C reactive protein levels are done along with placental histopathology to detect chorioamnionitis. It is one of the most significant causes of high perinatal morbidity and mortality. Aim and Objective: To determine c-reactive protein levels and placental histopathology in premature rupture of membranes for maternal chorioamnionitis. Methodology: Prospective study was conducted in a tertiary care university medical college hospital and research center in western Maharashtra. A total 250 pregnant women reported with per vaginal leak during the study period and CRP levels were sent along with urine culture sensitivity and high vaginal swab, post delivery the placenta was sent for histopathology were included in the study analysis. Results: The histopathology was done in all 250 pregnant women, chorioamnionitis was evident in 46 pregnant women. This gives the incidence of 18.4% of chorioamnionitis in the study population. The sensitivity for CRP was calculated to be 15.22%, with a specificity of 99.02%, positive and negative predictive values of 77.78% and 83.82%, respectively, with an accuracy of 83.60%. Conclusion: Normal CRP level has good predictive values to rule out maternal chorioamnionitis. But raised single CRP level has low sensitivity to predict for histological chorioamnionitis prior to its clinical expression.

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