Abstract

Background and Objective: Catheter-Associated Urinary Tract Infections (CAUTI) are a primary concern in healthcare, leading to increased mortality and morbidity among critically ill patients. This study aimed to identify uropathogens causing CAUTI and assess their antibiotic sensitivity/resistance. Methods: This study was conducted on 100 patients, all aged 18 or above, admitted for more than 48 hours with Foley catheters in place. Microbiologically, we classified the patients confirmed (mCAUTI) and clinically suspected (cCAUTI) based on urine culture results. Results: Out of 100 patients, 21 had positive urine cultures (mCAUTI), while 79 clinically suspected CAUTI cases were culture-negative (cCAUTI). Fever was the most prevalent symptom (67 patients), followed by genitourinary complaints, shock, and altered sensorium. Escherichia coli was the primary isolate among mCAUTI cases, followed by Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus spp., Enterobacter, and Pseudomonas aeruginosa. Imipenem demonstrated the highest sensitivity against gram-negative isolates, while grampositive isolates exhibited significant drug resistance. Conclusion: The study highlights E. coli and emerging Klebsiella pneumoniae as major CAUTI culprits with rising drug resistance. Urgent, cautious antibiotic practices are vital. Limiting catheter use, stringent aseptic measures, and timely removal are key to reducing CAUTI. Imipenem stands out as the most effective antibiotic, urging its careful use against CAUTI-causing pathogens.

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