Home > Journals > Indian Journal of Dental Education

Indian Journal of Dental Education

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Assessment of Homocysteine and Methylmalonic Acid in Saliva and its Correlation with Serum Vitamin B12 in Chronic Periodontitis Patients with or without Type 2 Diabetes

Ranganath Venugopal, Head of Department, Department of periodontology, Aecs Maaruti College of Dental Sciences and Research Centre, Bengaluru. , Shruthy R1 , Ranganath Venugopal2 , Rachana C3 , Manoranjan S J4 , Iswariya M5 , Shali Kokila J

Author Information

Licence:



Indian Journal of Dental Education 13(3):p 108-116, July – September 2020. | DOI: dx.doi.org/10.21088/ijde.0974.6099.13320.2

How Cite This Article:

Shruthy R, Ranganath Venugopal, Rachana C et. al., Assessment of Homocysteine and Methylmalonic Acid in Saliva and its
Correlation with Serum Vitamin B12 in Chronic Periodontitis Patients with or without Type 2 Diabetes. J Dent Educ. 2020;13(3):107–
115.
 

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background: Chronic periodontitis and Diabetes are common chronic diseases in the world. The aim of this study was to investigate the role of two biomarkers namely Homocysteine (Hcy) and Methylmalonic acid (MMA) in chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM) patients and also to evaluate its correlation with serum vitamin B12 levels. Methodology: 85 adults were recruited and divided into five groups as follows:

Group 1:17 healthy individuals without CP and T2DM; Group 2: 17 subjects with CP and without T2DM; Group 3: 17 subjects
with T2DM without CP; Group 4: 17 subjects with T2DM (controlled) and CP; Group 5: 17 subjects with T2DM (uncontrolled) and CP. Plaque index (PI), Gingival index (GI), Probing pocket depth (PPD) and Clinical attachment level (CAL) were assessed. Fasting blood sugar (FBS) levels, HbA1c and Vitamin B12 levels were evaluated. Unstimulated salivary samples were collected for assessment of salivary Hcy and MMAusing ELISA. Results:The probing depth and clinical attachment level was found to be elevated in chronic periodontitis and chronic
periodontitis with diabetes mellitus patients. The levels of Hcy were found to be elevated in group 5, followed by group 4, 3, 2 and 1. Elevated levels of MMA were seen in group 5 and 4equally. A statistically significant correlation betweenparameterssuchasPI,GI,PPD,CAL,FBS,HbA1candsalivarybiomarkerswereseen(p<0.05).Anegative
correlation between Hcy, MMA and serum Vitamin B12 levels were recorded. Conclusion: Elevated levels of salivary Hcy and MMAseen in chronic periodontitis and diabetes mellitus patients, suggesting their interrelationship. The levels of homocysteine and methylmalonic acid are inversely correlated with serum vitamin B12 levels.


Keywords: Diabetes Mellitus; Chronic periodontitis; Biomarkers; Vitamin B12; Methylmalonic acid; Homocysteine
 

References

No records found.


About this article

Cite this article

Shruthy R, Ranganath Venugopal, Rachana C et. al., Assessment of Homocysteine and Methylmalonic Acid in Saliva and its
Correlation with Serum Vitamin B12 in Chronic Periodontitis Patients with or without Type 2 Diabetes. J Dent Educ. 2020;13(3):107–
115.
 

Licence:



Received Accepted Published
N/A N/A N/A
DOI: dx.doi.org/10.21088/ijde.0974.6099.13320.2

Keywords


Article Level Metrics

Last Updated

Sunday 18 October 2026, 20:42:48 (IST)

3439

Accesses

9
611
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share