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Dipto

Editorial Board Member

Dr. Dipto Sinha

  • Address : Post Doctoral Fellow, Laboratoire Adaptation Et, Microorganisms · Intracellular Parasitism, Laboratoire Adaptation Et, Microorganisms · Intracellular Parasitism, University Joseph Fourier, France
  • E-Mail : diptosinhatmv@gmail.com

Research Interests :


Introduction


I am Dr. Dipto Sinha, a dedicated molecular parasitologist with a robust foundation and over a decade of specialized experience focused on unraveling the complex cell biology of the malaria parasite, Plasmodium falciparum. My career began with comprehensive research fellowships at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in New Delhi, where I developed a strong grounding in essential laboratory techniques and the mechanisms of parasitic growth. This foundational work culminated in my doctoral studies at the Bernhard-Nocht-Institute for Tropical Medicine (BNITM), University of Hamburg, Germany. My Ph.D. research specifically explored critical metabolic and survival pathways within the parasite, leading to significant contributions concerning the role of key protease machinery in parasitic survival and cell death.

Following my doctoral degree, I expanded my scope through an extensive Postdoctoral Fellowship, supported by the PARAFRAP alliance, at the University Joseph Fourier in Grenoble, France. Here, my focus shifted to the broader mechanisms of intracellular parasitism and host-microorganism adaptation, which has further deepened my expertise in host-pathogen interactions. Technically, I possess advanced skills in molecular cloning and the sophisticated generation of transgenic parasite cell lines, complemented by high-level proficiency in analytical tools like microscopy and FACS. A key highlight of my research output includes co-authoring several high-impact publications and, notably, contributing to a patent for the use of small peptides as novel anti-malarial drugs, demonstrating a clear focus on translational research and therapeutic innovation.

Overall, my professional trajectory is characterized by an unwavering dedication to excellence in parasite cell biology, supported by international training across leading institutions in India, Germany, and France. My diverse experience, combined with the successful securing of prestigious fellowships like D.A.A.D., has prepared me for collaborative, high-stakes research environments. I am passionate about leveraging my in-depth understanding of parasite metabolism and cellular architecture to identify and validate next-generation drug targets. I am now looking forward to applying this comprehensive skill set and translational mindset to a challenging role where I can continue to drive significant scientific breakthroughs in infectious disease research.


AFFILIATION


Post Doctoral Fellow, Laboratoire Adaptation Et, Microorganisms · Intracellular Parasitism

Laboratoire Adaptation Et, Microorganisms · Intracellular Parasitism

University Joseph Fourier

CNRS, Grenoble, France

Grenoble

France

38000

Email : diptosinhatmv@gmail.com


RESEARCH IDS



RESEARCH INTERESTS


# Area
1. Molecular Parasitology
2. Parasite Biology
3. Parasite Culture
4. Parasitic Diseases
5. Plasmodium
6. Protein-Protein Interaction
7. Serine Proteases

PAPERS PUBLISHED


# Article Title Year
1. The prokaryotic ClpQ protease plays a key role in growth and development of mitochondria in Plasmodium falciparum. Jain S, Rathore S, Asad M, Hossain M E, Sinha D, Datta G, Mohmmed A. Cell Microbiol. 2013 Oct; 15(10):1660-73 2013
2. Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum. El Bakkouri M, Rathore S, Calmettes C, Wernimont A K, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry W A. J Biol Chem. 2013 Jan 11; 288(2):1022-31 2013
3. Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite. Kono M, Herrmann S, Loughran N B, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U, Heussler V, Spielmann T, Parkinson J, Gilberger T. W. Mol Biol Evol. 2012 Sep; 29(9):2113-32 2012
4. Design and synthesis of protein - protein interaction mimics as Plasmodium falciparum protease, falcipain-2 inhibitors. Rizzi L, Sundararaman S, Cendic K, Vaiana N, Korde R, Sinha D, Mohmmed A, Malhotra P, Romeo S. Eur J Med Chem. 2011 Jun; 46(6):2083-90 2011
5. Disruption of mitochondrial protease machinery in Plasmodium falciparum is an intrinsic signal for parasite cell death. Rathore S*, Jain S*, Sinha D*, Gupta M, Asad M, Srivastava A, Narayanan M S, Ramasamy G, Chauhan V S, Gupta D, Mohmmed A. Cell Death Dis. 2011 Nov 24; 2:e231. * Contributed equally 2011
6. A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development. Rathore, S*, Sinha D*, Asad M*, Böttcher T, Afrin F, Chauhan V S, Gupta D, Sieber S A, Mohmmed A. Mol Microbiol. 2010 Jun 10. * Contributed equally 2010
7. A novel Plasmodium falciparum erythrocyte binding protein associated with the merozoite surface, Pf DBLMSP. Wickramarachchi T, Cabrera A L, Sinha D, Dhawan S, Chandran T, Devi Y S, Kono M, Spielmann T, Gilberger T W, Chauhan V S, Mohmmed A. Int J Parasitol. 2009 Jun; 39(7):763-73 2009

BOOKS PUBLISHED


# Title Publication Year

BOOK CHAPTERS PUBLISHED


# Chapter Title Book Title Publication Year

ACADEMIC PROFILE


# Examination Passing Year Country
1. Ph.D. in molecular parasitology of malaria 2014 Germany
2. M.Sc 2006 India
3. B.Sc (Hons) Biotechnology 2004 India

EMPLOYMENT DETAILS


# Institution Position Country Service Period
Total Period : 0 years, 0 months, 0 days

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