RFP Indian Journal of Hospital Infection

Recognition of TP53’s prominent role in protection from cancer has boosted a huge amount of scientific reports (around 40000) describing the function of TP53 as a tumour suppressor. Quite an unusual feature of a tumour suppressor was noted – TP53 is point mutated rather than inactivated in cancers and is highly expressed in tumours. Mutation of TP53 gene confers novel oncogenic properties on TP53 protein.
 

As a broad timeline, infections happening in excess of forty eight hours after admission to the medical health centres or hospitals are typically viewed as Hospital Associated Infections (HAI’s)(WHO).These HAI’s that patients gain throughout getting treatment for different medical conditions are likewise called nosocomial infections. Every year, numerous lives are lost in light of the spread of infections in hospitals. HAIs are a reason for noteworthy morbidity and mortality in patients receiving treatment, and the immediate and aberrant expenses of these infections drain the effectively restricted money related assets allotted to hospitals. It is evaluated by the Centers for Disease Control and Prevention that two million patients experience the ill effects of HAI’s consistently and almost one lakh of them die.Annually HAI result in upto $4.5 billion extra medicinal services expenses. Therefore emergency clinics should concoct an inhouse mindfulness program where staff individuals, patients and their relatives can be taught on keeping up cleanliness and build up a comprehension of disease aversion and its financial ramifications which will permit disease control experts to settle on better educated choices.

Introduction:Endotracheal suctioning (ETS) is one of the most common procedures performed in patients with artificial airways. It is a component of bronchial hygiene therapy and mechanical ventilation that involves the mechanical aspiration of pulmonary secretions from a patient’s artificial airway to prevent its obstruction. The procedure includes patient preparation, the suctioning event, post procedure care. The objectives of the study were to (1) To observe the existing practice regarding endotracheal suctioning among staff nurses. (2) To evaluate practice regarding endotracheal suctioning among staff nurses after demonstration. (3) To find out association of practice with their selected demographic variables. Method: One group pretest and post-test pre-experimental study design by using structured observation checklist to assess practice of endotracheal suctioning among staff nurses. The study was conducted among 30 staff nurses working in ICU of selected hospital by using non probability convenient sampling technique. The data was collected and analyzed based on objectives of the study using descriptive and inferential statistics. Result: The overall comparison of pre-test practice score and post-test practice score of staff nurses regarding endotracheal suctioning mean of pre-test practice score was 7.57 and post-test practice score was 12.17. The tabulated ‘t’ value was 1.69 and the calculated ‘t’ value was 13.73 are much higher than the tabulated value at p<0.05 level of significance for overall practice score of subjects which was statistically acceptable level of significance. Hence it was statistically interpreted that the demonstration was an effective tool in improving the practice regarding endotracheal suctioning among subjects. Conclusion: The investigator concludes that the demonstration was effective and will help to improve the practice of staff nurses.

Introduction: Urinary tract infection (UTI) is one of the most common bacterial infections in developing countries. We face difficulties in choosing antibiotics during treatment of UTI due to emerging antimicrobial resistance among the predominant uropathogens. Aims: This study was undertaken to know the prevalence and antibiogram of uropathogens in our hospital and to determine the type and antibiotic resistance pattern of the urinary pathogens. Materials and Methods: The study was carried out on 103 consecutive patients suffered from UTI admitted at in-patient department of School of Tropical Medicine, Kolkata during one year. Results: In the present study we isolated 103 bacteria in suspected cases of UTI. Among the bacterial profile of UTI, Escherichia coli was the predominant isolate (36.89%) followed by Klebsiella species, Enterococcus species, Staphylococcus species, Pseudomonas aeruginosa and Citrobacter species. We found only one each case of Acinetobacter species, Serratia and Stenotrophomonas maltophilia. Conclusion:Emerging bacterial drug resistance has both clinical and financial implications for therapeutic purpose. Spectrum of bacterial drug resistance in an institution is important for epidemiological as well as clinical purposes.