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TP53 as a Tumor Suppressor Gene

Syed Mudassar , Mosin S Khan , Roohi Ashraf , Aaliya Shah , Syed Mudassar

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RFP Indian Journal of Hospital Infection 1(2):p 93-104, July-December 2019. | DOI:

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Abstract

Recognition of TP53’s prominent role in protection from cancer has boosted a huge amount of scientific reports (around 40000) describing the function of TP53 as a tumour suppressor. Quite an unusual feature of a tumour suppressor was noted – TP53 is point mutated rather than inactivated in cancers and is highly expressed in tumours. Mutation of TP53 gene confers novel oncogenic properties on TP53 protein.
 

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Cancer; TP53; Tumor suppressor gene; Polymorphism

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