Indian Journal of Genetics and Molecular Research

The purpose behind this case study is to examine the function of thyroid gland, understand the regulation of thyroid hormones, to correlate the symptoms with respect to thyroid dysfunction and its associated consequencesfollowed by clinical interventionsand the pharmaceutical care plan. A female patient with an age of 48 years old is suffering from hypothyroidism and was followed up, information was collected and analyzed. Pedigree analysis revealed that there is an important component of genetics in causation of disease and is reflected to be due to consanguineous marriages in previous generations of the patient which must have added the risk over general population, another consideration is the occurrence affected relatives who are third degree relatedand can support in the genetic component of the disease.

Starting from the encounter of the first case of H1N1 influenza virus in the year 2009 reported from the town of Mexico to its lay out across the globe; H1N1 virus has affected thousands of people in India. Since then this seasonal virus keeps on mutating (S181T and I312V) becoming more and more harmful and dangerous causing various serious complications. With its ability to regenerate and mutate at a faster rate this virus has RNA as its genetic material which is a combination of three different species; humans, avian and swine, targeting a larger spectrum of hosts turning out to be extra severe. Evidence have shown that the elderly and children are the most affected by the virus due to low immune response by the body. Common symptoms of H1N1 include fever, chills, sore throat ,etc. The situation may turn fatal if left untreated.

Background: Chronic myeloid leukemia (CML) is a clonal malignant disorder of hematopoietic stem cell characterized by the classical chromosomal translocation, Philadelphia (Ph) chromosome in more than 90% of the patients. CML is associated with significantly high granulocyte numbers in the bone marrow and peripheral blood. Materials and Methods: This is a retrospective study conducted at the All India Institute of Medical Sciences, New Delhi, India aimed to evaluate the incidence and characteristics of CML patients. We have evaluated the demographic, clinical, and hematological data of 158 consecutive patients who visited the hospital from 2012 to 2014. Results: The diagnosis and stage of CML were determined based on the World Health Organization criteria, followed by the polymerase chain reaction. 158 patients evaluated in this study, consist of males (n = 98, 62%) which was higher than females (n = 60, 38%)( M:F::1.6:1). The mean + SD of male and female was 35.6 + 12.7, mean + SD of males was ( 35.7+ 13.6) and mean + SD of females was ( 35.4+11.3). While 17 (10.7%) patients were below 20 years of age, 94 (59.4%) were between 21–40 years, 40 (25.3%) were between 41–60 years, and 7 (4.4%) were more than 60 years of age. The predominance of younger patients (59.4.%) were belong to the age group of 21-40 years. While the most predominant symptom was fatigue and bone pain, the most common clinical sign was hepato-splenomegaly, followed by remarkable weight loss, and epistaxis. Conclusion: A patient with an increased WBC count, weakness, bone pain, low LAP score and hepatosplenomegaly should clearly be evaluated for CML.