Indian Journal of Diabetes and Endocrinology

Insulin resistance linked to type 2 diabetes causes syndrome X, which worsens life quality by causing CD, Nard, FLUS, malignancies, and headaches. Complications linked to diabetes mellitus (DM) are linked to ethnological variance, as demonstrated by a separate look at of the Abelallele of the GLUI1 gene. The relative expression fees of such GLUT transporters are being investigated. Is a predictive factor for some situation related diabetes, such as gestational diabetes. Immuno cytochemistry and drift cytometry revealed a higher presence of GLUT4 inside the lymphocytes of type 2 diabetic patients, although this is no longer the case. Diabetes mellitus is a chronic metabolic disorder with significant social, health, and economic consequences. It is estimated that 285 million people worldwide (approximately 6.4 percent of the adult population) were affected by this disease in 2010. In the absence of better control or cure, this figure is expected to rise to 430 million. The main causes of the increase are an ageing population and obesity. Furthermore, it has been demonstrated that nearly half of all putative diabetics are not diagnosed until 10 years after the onset of the disease, implying that the true global prevalence of diabetes must be enormous.

Objective: To explore the relationship of depression with quality of life among type 2 Diabetic patients in comparison with healthy individuals (controls). Methodology: the present study was case control study. The data was collected from SVIMS Endocrinology OPD in Tirupati. during the period of January 2016 to July 2016. There were 300 participants including 150 type 2 DM patients, whilst for a comparative assessment a group of 150 healthy individuals (age and gender matched) were also selected as a control to meet the purpose of the study. Subjects age range was set between 35-65 years. The study comprised of type 2 DM patients. While inclusion criteria the type 2 DM patients with duration of 5 years and above attending OPD SVIMS, were selected as a cases and healthy individuals (controls) were selected from the hospital staff. Sample was selected by simple random sampling technique using random number generated in MS excel. Beck depression inventory (BDI-II) developed by Aeronbeck in 1996 and WHO quality of life scale (QOL BREF) by Frisch 1994 were used for data collection. The data was interpreted through SPSS-20. Results: the study findings showed that significant but negative relation between depression scores and quality of life. Good quality of life was negatively corelated in comparison to the depression in diabetic patients (γ = -0.617**, p<0.01). It was also identified that there was significant difference among gender and residence with respect to mean scores of Quality of Life at p>< 0.05 level, educational status, occupational status and monthly income at p < 0.01 level and there were also significant difference among educational status, occupational status and monthly income with respect to mean scores of depression at p<0.01 level and with regard to residence and living status at p>< 0.05 level. n observed linking depression and sub-scales of quality of life indicating that high depression scores may lead to lower physical and psychological health impacting social relationship and environmental health.

Diabetic foot ulcers is a devastating component of diabetes progression and are caused by loss of glycemic control, peripheral neuropathy, peripheral vascular disease, and immunosuppression. An estimated 15% of patients with diabetes have diabetic foot ulcers.1 Hybrid endovascular and open reconstructions are used increasingly often for multilevel revascularization and management of lower limb ulcers, especially for lower limb ischaemia. In this study hybrid reconstruction was performed to improve outcome of wound healing in adult diabetic foot patient.