Indian Journal of Diabetes and Endocrinology

Thalassemia is an inherited autosomal recessive blood disorder. Which results in excessive destruction of Red blood cells and further leads to anemia. Thalassemia’sare prevalent World wide with 16,800 death and 4,39,000 severe cases in 2015. According to 2017 data 80 million are carriers of beta thalassemia, Beta thalassemia is more common in children. Thalassemia is caused by variant or missing genes that affects how the body make hemoglobin. Which people having thalassemia Make less hemoglobin and fewer Circulating red blood cells than normal results in mild or severe anemia.

Modified Loub Job’ procedure is a liposuction assisted removal of the fat to reduce the bulk of the foot. It’s a reconstructive procedure for congenital condition. The term ‘Modified Loub Job’ is introduced for the first time in literature. In our study, modified loub job was performed in a subject with left big toe macrodactyly. Keywords: Loub Job, Foot Macrodactyly, Liposuction.

Objective: Gestational Diabetes is a growing concern worldwide due to pregnancy outcome risks. Along with Lifestyle modifications for the prevention and maintaince of euglycemia standard insulin supplementation and oral hypoglycemic drug Metformin is being used for the pharmacological management. This study aims to compare the efficacy of Metformin and Insulin treatment groups. Methods: This is an Observational comparative study in maternal hyperglycemia subjects prescribed with insulin and metformin for atleast three months during their gestation period. Clinical parameters compared are Fasting blood glucose, Postprandial blood glucose, HbA1c, which are analysed and the data is represented in average with standard deviation. Results: The mean difference between Group Itreated with metformin and Group II treated with insulin of Fasting Blood glucose, Post Prandial Blood glucose, HbA1c in are -13.94±18.22 mg/dl, -44.16±8.99mg/dl, -1.4±0.2% respectively. Conclusion: Metformin is less effective than standard Insulin regimen, but is able to maintain Glycemic control.

Objective: Gestational Diabetes is a growing concern worldwide due to pregnancy outcome risks. Along with Lifestyle modifications for the prevention and maintaince of euglycemia standard insulin supplementation and oral hypoglycemic drug Metformin is being used for the pharmacological management. This study aims to compare the efficacy of Metformin and Insulin treatment groups. Methods: This is an Observational comparative study in maternal hyperglycemia subjects prescribed with insulin and metformin for atleast three months during their gestation period. Clinical parameters compared are Fasting blood glucose, Postprandial blood glucose, HbA1c, which are analysed and the data is represented in average with standard deviation. Results: The mean difference between Group Itreated with metformin and Group II treated with insulin of Fasting Blood glucose, Post Prandial Blood glucose, HbA1c in are -13.94±18.22 mg/dl, -44.16±8.99mg/dl, -1.4±0.2% respectively. Conclusion: Metformin is less effective than standard Insulin regimen, but is able to maintain Glycemic control.