Indian Journal of Cancer Education and Research

The objective of this short communication was to inform evidence through an overview of reviews of cancer pain and quality of life. Theoretical understanding of cancer pain should involve a combination of biochemical/neurobiological factors,together with social/racial and ethnocultural influences of pain and quality of life in people with cancer. Both generic and disease-specific self-reported questionnaires should be used to explore utility and efficacy of interventions and also to study the multidimensional impact of cancer pain on quality of life. Multimodal management with treatment options ranging from educational, medical/pharmacological (bisphosphonates), surgical (nerveblocks) and radiation therapy should be incorporated into supportive cancer care. Future research should address caregiver and family issues, and explore the mechanism-based paradigm in cancer pain in order to effectively enhance quality of life of people with cancer pain.

Keywords: Palliative oncology; Cancer anesthesiology; Quality of life; Cancer pain.

Sebaceous Carcinoma is an uncommon, aggressive malignant tumor derived from the adnexal epithelium of sebaceous gland either from ocular or extra ocular sites. Extra ocular sites being very uncommon and forms one-fourth of all sebaceous carcinomas.Patients presenting in extremity are rarest and have a high mortality rate. Here we present one case which presented with multiple orange colored nodular lesions over dorsum of right hand, it recurred and progressed very fast after surgery and no response was seen with chemotherapy.

Keywords: Upper extremity; Sebaceous carcinoma.

The European Organization for Research and Treatment of Cancer- Quality of Life Questionnaire 30-Item Core Version (EORTC-QLQ-C30) is globally regarded as a gold-standard self-reported evaluation tool for Health-related quality of life (HRQoL) for use in cancer practice, education, research and administration. The objective of this review article was to address its applicability in various languages through studies on cross-cultural adaptation and translation-validation. There were 19 studies found on 13 languages (Chinese=4; Turkish=3; Taiwan Chinese=2; other ten languages=1 each), all of them reporting acceptable reliability, validity and responsiveness for the translated versions of EORTCQLQ-C30 for evaluating HRQoL in cancer patients in a variety of settings and situations. There is need for validating EORTC-QLQ-C30 questionnaire into Indian languages to facilitate its routine use in oncology and palliative care settings.

Keywords: Oncological evaluation; Quality of life;Psychooncology; EORTC-QLQ-C30.

Now days because of various factors malignancy incidences are increasing in all levels of socioeconomic strata of ccommunities. So the main aim of this article is that new generation of doctors should be aware of this all pionears includingpaediatricians. 

Keywords: Oncology; Paediatrics; Pioneers; Old age.

Normal cells and cancer cells can be differentiated clearly during hypoglycemia because of the difference in the number of insulin receptors and the biologic response modification which insulin produces. This helps in targeting the chemotherapy drugs more specifically and effectively inside the cells. This occurs with reduced doses of chemotherapy drugs and minimizes their side effects. With this aim two patients with advanced and recurrent Head and Neck cancer were included in this pilot study and about one tenth the dose of chemotherapy with Carboplatin 75 mg and Gemcitabine 200 mg were given once weekly for six weeks during period of hypoglycemia produced every time by giving intravenous Insulin 0.1ug/kg. A complete response was achieved in one patient and other patient had a partial response and which responded to radiotherapy achieving a complete response. There was no side effect of the drug or hypoglycemia recorded by the patient. The survival was 11 months and 8 months respectively concluding that even one tenth the dose of chemotherapy given during hypoglycemia gives a very good clinical response with no side effects of the drugs. 

Keywords: Insulin potentiation; Hypoglycemia;Low dose chemotherapy; Recurrent cancer.