Background: Palmoplantar warts are always challenging to the treating dermatologist because of their high rates of failures and recurrences. First line treatment modalities available currently are associated with recurrences and second line modalities are associated with scarring. Clinical trials with MMR suggests that this approach could speed up the resolution of recalcitrant warts. Objective: To evaluate efficacy and safety of intralesional MMR vaccine in treatment of recalcitrant palmoplantar warts by comparing it with intralesional distilled water. Materials and methods: Seventy clinically diagnosed patients were divided into a study group and a control group. MMR injections (0.5 ml) were administered to the study group patients every 3 weeks to the single largest wart. Distilled water (0.5 ml) was administered to the control group at similar intervals. Follow up of patients in both groups were done every month after completion of treatment for 9 months for result, side effects and recurrence. Result: Among 64 patients who completed the study, 32 patients received MMR and 32 patients received distilled water. An 81.30% reduction of wart size and number was noted in study group were as only a 18.80% reduction was seen in control group which was statistically highly significant (p value < 0.001).

Keywords: Warts; MMR vaccine; Distilled water.