AbstractThe purpose behind this case study is to examine the function of thyroid gland, understand the regulation of thyroid hormones, to correlate the symptoms with respect to thyroid dysfunction and its associated consequencesfollowed by clinical interventionsand the pharmaceutical care plan. A female patient with an age of 48 years old is suffering from hypothyroidism and was followed up, information was collected and analyzed. Pedigree analysis revealed that there is an important component of genetics in causation of disease and is reflected to be due to consanguineous marriages in previous generations of the patient which must have added the risk over general population, another consideration is the occurrence affected relatives who are third degree relatedand can support in the genetic component of the disease.