Carious exposure of young permanent tooth during the time of root development may lead to caseation of root completion, which leads to the absence of physiological apex closure and makes any endodontic treatment a challenge. For the success of the treatment and to create an apical barrier onto which obturating materials are condensed. This can be achieved in many ways traditionally; calcium hydroxide was used but due to drawbacks like long treatment duration and unpredictable results it is replaced by materials like mineral trioxide aggregate (MTA) and regenerative endodontics which appears as a newer modality to treat young permanent tooth with open apex. The only drawback is the over extrusion of MTA. To encounter that a favorable matrix is being used called Platelet-rich fibrin (PRF), this can be used as an apical matrix onto which MTA is condensed and an apical seal with favorable treatment outcomes can be achieved