This study was undertaken to derive the prevalence rate of fasciolosis disease in sheep and goats by collection of data regarding condemnation of liver samples due to fasciolosis from municipal slaughter house of Tirupati, over a period of one year from September 2012 to August 2013. During the study period a total of 35899 sheep and 25644 goats were slaughtered and 3278 (9.13%) and 2090 (8.15%) livers of sheep and goats respectively were condemned due to fasciolosis. Of the slaughtered sheep and goats a significantly (p<0.05) higher prevalence of fasciolosis was recorded in sheep than in goats. Sex wise occurrence of fasciolosis in sheep and goats revealed that fasciolosis was significantly more prevalent in females than in males. Seasonal fluctuations were recorded on occurrence of liver fluke infection and highest percent of liver condemnations were observed during the rainy season followed by summer and winter. The overall high frequency of fasciolosis infection causes considerable economic losses and also poses a public health risk to meat consumers because of its zoonotic nature.