Quality and safety are the two most essential aspects for the acceptance of drugs. The drug, which is going to be administered in to the human body, should be standard and should not produce any kind of untoward effects after its administration. A drug fulfilling the criterion of a standard drug will always become panacea provided, if it is used properly. On the other hand, a poorly prepared or manufactured drug however used skillfully, will always prove to be a poison. Seers of Ayurveda considered these aspects and stressed their significance in respective classics. In due course of time, considering the enormous growth of pharmaceutical sector; Governments established different Drug Regulating Mechanisms to regulate entering of spurious drugs in to the market. The Drugs & Cosmetics Act & Rules governs the Drug Regulating Mechanisms to maximum extent in India. Considering the need of the industry, the rules will be amended at regular intervals. Here an attempt has been made to compile certain important amendments took place in recent past.

Keywords: Ayurveda; Drugs & Cosmetics Act; Drug Regulating Mechanism.