Ageing is a process that can affect almost all the systems in the body. Some people live up to the age of 85 in a very good physical and mental condition while others live with extensive cognitive and physical disorders already by the age of 60 or even before. This is a fact to think logically that why a person's biological age is more indicative of their health than their chronological age. Why are some people more susceptible to develop physical as well as mental deterioration as they get older, while others remain healthy and sharp to an older age? More research is being conducted into the process of ageing and ways in which the process can be slowed. Although researchers explored many interesting possible biomarkers of ageing, no biomarker was successfully identified and validated. Ayurveda has not only paid attention towards healing of ailments, but also retarding of ageing & healthy longevity for which multi-dimensional strategy known as Rasayana has been introduced. According to Ayurveda, all humors (Tridosha), essential tissues (Saptadhatu), indriya (Organs), Srotas (Body channels) and Agni (Digestive & Metabolic capacity) are affected in ageing process. Though most of those features are subjective, they could be measured by careful assessment and suitable grading. This paper demonstrates gradation of bodily changes crated by deranged Tridosha and Saptadhatu in association with ageing.

Key Words: Ageing, Biomarker, Ayurveda, Rasayana, Tridosha, Saptadhatu, Srotas, Indriya, Agni.