Background and Objectives: A huge number of drugs have been emphasized in Ayurveda like akaradhwaja (mercurial preparation), Guduchi Ghana (dried extract of Tinospora cordifolia Linn) etc. in the treatment of Madhumeha (Diabetes mellitus). Nevertheless, their efficacy was not reported till date. Considering this, it is attempted to evaluate its efficacy in the patients of Type-II Diabetes Mellitus. Methods: 34 patients were screened for diabetes in the OPD of Ayurvedic Hospital, IPGT & RA, Gujarat Ayurved University, Jamnagar. Signs and symptoms of diabetes and history were recorded. 125 mg of Makaradhwaja and 125 mg of Guduchi Ghana with honey were administered for four weeks daily to the patient. Patients follow up was carried out for next four weeks. Results: Significant decrease in symptoms of diabetes and fasting and postprandial sugar level were observed (P<0.001) insignificant decrease in serum urea, serum creatinine, serum triglyceride and SGPT levels were observed. Minimal increase in serum cholesterol, total protein and SGOT levels were observed. Conclusion: Makaradhwaja at significant extent attenuated symptoms of Type-II diabetes mellitus. Both fasting and post prandial sugar levels were decreased significantly. Makaradhwaja has anti hyperglycemic effect as well as synergistic action with dried extract of Tinospora cordifolia and Honey. 

Keywords: Diabetes Mellitus; Guduchi Ghana; Kupipakwa Rasayana; Madhumeha; Makaradhwaja.