Panchavalkal is the formulation with barks of five trees viz. Vata (Ficus benghalensis Linn), Udumbara (Ficus glomerata Roxb.), Ashwatha (Ficus religiosa Linn.), Parish (Thespesia populnea Soland ex corea.) and Plaksha (Ficus lacor Buch-Ham.). This polyherbal formulation showed in-vitro antimicrobial activity which supports the activity mentioned in Ayurved classics as effective in Vrana (wounds) as well as Shotha (inflammations). These five herbs have the potential for Vrana Shodhan and Vrana Ropan properties due their Kashaya (astringent) rasa predominance. The aim of this review article is to highlight the uses and potential of Panchavalkal for management of inflammation, wounds, antiseptic and antimicrobial. The data related to the Panchavalkal has been collected by hand search and through the internet which was published in the scientific journals. The studies carried out on Panchavalkal are preclinical as well as clinical studies. This article gives direction to the new researcher for further study on Panchavalkal for its antimicrobial activity in different forms. 

Keywords: Antimicrobial; Anti-inflammatory; Ayurveda; Panchavalka; Shotha;  Shodhan, Ropan;  Vrana; Wound healing.