The quality control assessment of herbo-mineral formulations is of great significance in order to justify their acceptability in modern system of medicine though the drug may be therapeutically potent. Ayurveda and its rapidly increasing use by public have given rise to many newer issues and challenges.Ayurvedic formulations prepared by several manufactures are guaranteed to carry out the quality control test as per preliminary guidelines given by CCRAS (Central Council of Research in Ayurveda and Siddha). Though the standards are followed, still the variability in their results has been observed when compared between same formulations.Dushivishari Agada is one such herbo-mineral formulation consisting of 13 drugs & used for treatment in Dushivisha janya vikaras. An attempt is made here to compare Dushivishari agada prepared by GMP certified pharmacy with in-house preparation. Results revealed that the both the samples differ in their organoleptics, pH and Physicochemical properties, Thin layered chromatographic study showed sample (a) and (b) different number of bands at the wavelength of 255nm and 365nm, major difference was seen in disintegration time and hardness of sample (a) i.e., hardness is 10.4 and disintegrated in 1hr, whereas sample (b) hardness is 4.4, but disintegrated in 15min.  Statistical analysis shows significant variations in both the samples. The physicochemical data of this comparative study assists in maintaining the standard limits of Dushivishari agada.

Key words: Herbo-Minerals Formulation; Physicochemical Analysis; TLC.