Ardhavabhedaka is the vishishtha shiroroga of shiras, which has headache as a cardinal feature. Exactly
the swabhava of Ardhavabhedaka cannot be compared to the modern diseases. A near comparison can be given as a unilateral headache. This term has been given under the study of migraine, which is one of the vascular types of headaches having unilateral manifestation with periodical relapses.The lakshanas in Ardhavabhedaka are Toda, Bhrama, Shanka, Bhru, Lalata, Karnashula, Skandagraha, Ghrana srava, Prakashaasahishnuta, Shabda asahishnuta[1], if remain untreated leads to grievous complications like Nayana vinasha, Srotru vinasha.[2] Migraine is characterized by periodic, episodic, throbbing, pulsatile unilateral headache with elementary symptoms like nausea/vomiting/constipation/diarrhea/violent throbbing pain. Pain is located in one/half of the Temporal, Supra-orbital, Frontal, Retro bulbar, Partial, Posterior auricular, Occipital region, Upper or Lower teeth, base of the nose and down as far as tip of the shoulder.[3]
The approach to treatment for Migraine in modern system is the usage of analgesics, systemic treatment, metabolic corrections, refractive error corrections[4], etc. which more or less give temporary relief. So there is need for an optimum therapy which will decrease the intensity, delays the frequency and give longer better relief to the patients. In this connection this study was undertaken to evaluate the comparative effect of Agnikarma in group A and Nasya karma in group B. Agnikarma with Swarna shakakha at lalata pradesha until Samyak dagdhalaxanas were seen was carried out in group A and Nasyakarma for 7 days (8 drops in each nostril) with 7times Avrita ksheerabala taila in group B. Then follow up was done for 3 weeks after the treatment to assessthe results. To assess the efficacy of treatment, the symptoms of Ardhavabhedaka such as Shirashula (Unilateral headache), Avadhi (Duration of attacks), Vega (Frequency of attacks) and Doppler study: of both right and left superficial temporal arteries (systolic and diastolic velocities) were noted carefully before commencement and after completion of the treatment. Results in both groups were analyzed statistically by using Chi-square test, which showed highly significant results with Chi-square value = 8.118 and ‘P’ Value > .001.

Keywords: Ardhavabhedaka; Migraine; Agnikarma; Nasyakarma.