People are suffering from Mukhapak mostly the young generation due to busy and stressful life also other factors like irregular timing of diet and sleep, eating spicy and fast food, chewing of tobacco and Gutakhas. Aggravation of tridoshas mainly pitta corrupt the raktadhatu and causes Mukhapak (stomatitis). During the study project detailed study of previous work was done. All available information about materials was collected and studied in detail. For this study sixty patients were selected randomly and divided into two groups: Group A-Trial group & Group B- Control group Group A (trial group): Total number of patients are thirty. They were treated with Tab. Kamdudha systemically and JatyaditailPratisaran (locally). Tab. Kamdudha 500 mg. three times a day for seven days JatyaditailPratisaran 2-3 ml four times a day for seven days Group B (control group): Total number of patients are thirty. They were treated with Tab. Kamdudha systemically. Tab. Kamdudha 500 mg three times a day for seven days. Observations recorded for seven days with alternate day follow up. A special case paper was made for the study in which observations were made in tabular form and effect of Jatyaditail Pratisaran was analysed. According to observation statistical analysis was done. It showed that the above said Jatyaditailpratisaran with Tab. Kamdudha is more effective in Mukhapak and gives better result than Tab. Kamdudha alone.Jatyaditail is tridoshashamak, vranashodhak and vranaropak .JatyaditailPratisaran can be done easily for oral cavity. So it can be routinely used by patients of Mukhapak.

 Keywords: Mukhapak(stomatitis), Pratisarana and Jatyaditail.