Background: Prakriti (constitution) of a man has genetic and acquired aspect; the genetic aspect depends pon sperm and ovum, while acquired constitution develops in relation to environmental factors such as limate, season, time factor, age, race, familial inheritance. New approaches and development in modern cience improve and accelerate the concept of Prakriti. This short discourse gives us a clue to fundamentals of Prakriti as met with in Ayurveda and evidence based scientific supporting data validating and approving it. Aim and Objectives: To revalidate the Ayurvedic genetic concept of Prakriti in light of evidence based studies. Materials and Methods: Information extracted from various classics such as Brihattrayi (Charaka, Sushruta, Ashtanga Hridaya and Ashtanga Sangraha Samhita) and published information on recent research developments of Prakriti including original articles in Pubmed, Scopemed, Pubmed Central Databades, Dhara online database and other allied databases were taken into study for the review. Reported data was analyzed and represented for current review. Conclusion: Contemporary evidences confirm and establish Prakriti as genetic theory of modern science. The current work appears to be the first of its kind and can be considered as reference standards for future studies.

Keywords: Ayurveda; Personalized medicine; Prakriti; Genetics.