Pilonidal sinus can be correlated with Shalyajanya Nadivrana by Acharya Sushruta according to its pathophysiology and etiology. It is commonly seen in young age people in 2nd and 3rd decades and more prevalent in heavy motorvehicle drivers. Excision of Pilonidal sinus tract is the best choice of treatment for pilonidal sinus till date but the condition often reoccurs due to the failure in identifying and draining all the sinuses or residual hair in the cavity or low quality post-operative care This study includes, A case of 22 years old male patient having complaint of Pain and swelling in the lower back region (Natal cleft) along with on and off pus discharge from that swelling for the past two years, which was treated with Chedana (excision) of Nadi-vrana (Sinus tract) followed by proper post-operative care i.e. Vranasodhana with Panchvalkal Kwath and Vrana Ropana with Local application of Yastimadhu Malhara. The wound was completely healed within 60 days and follow up was taken for next 4 months and there was no recurrence was found during 4 months follow-up periods.