Currently world is looking towards alternative medicine or traditional Practices which are practiced widely for lifestyle disorders or for palliative care. Publicity and Marketing of Systems of traditional practices has been increased since a decade. Each System of Medicine is scientifically evident and is practiced either alone or along with Allopathy medications either on advise or by self-believing that medicines of alternate System are safe and can be taken along with modern medications. Here is a Systematic review on herbs which are used widely in traditional practices and their potential actions along with their possible interactions with drugs or pathways.

Keywords: Herb-Drug Interactions; Traditional medicine; Adverse effects.