The syndrome of Diabetes Mellitus is largely covered under the broad heading of Prameha. Ayurveda clearly mentioned role of unhealthy diet and unhealthy behavioral pattern in the pathophysiology of the disease Madhumeha. The diseases mainly related with the metabolic imbalance associated with the main dhatus like Rasa, Rakta, Mamsa, Meda causing unwanted accumulation of undigested matter i.e., Ama in the whole body with extra deranged quality Meda, so close resemblance between Madhumeha and Medoroga. The present study has been designed with the objectives to evaluate the role of shodhana therapy in the treatment modalities of DM. As already stated that the shodhana is needed for such patients and after shodhana, shaman therapy should be prescribed along with medohara drugs to have an effective control on this disease. For this purpose in Group 1; Madhumehahara yoga (Tejapatra, Mam ejaka, Jambu seeds, Avartaki pushpa each in equal part with three bhavanas of Karavellaka swarasa), Vidangadi Lauha (Vidanga, Nagara, Yavakshara, Tikshna Lauha Bhasma, Yava, Amalaki each in equal part) (Ch. Su. 1/23) and virechana (Virechana Yoga: Aragvadha Majja-15 gm, Haritaki churna-15 gm, katuki churna-5 gm in 160 ml water & boiled to get 40 ml of decoction. To this decoction 20 ml of castor oil along with 250 mg of Ichchabhedi rasa was added.) were selected. These drugs therapy were tried on 16 patients and effect was assessed on various parameters. The patients treated with Madhumehahara yoga and Vidangadi Lauha had shown highly significant relief in fasting, 1st hour blood sugar level & significant relief in 2nd hour blood sugar level whereas virechana has shown significant decrease in fasting, 1st hour & 2nd hour blood sugar level. Along with above pathophysiology and involved factors, classics mentioned the role of Vata mainly in Madhumeha, so a genuine attempt is made to rule out the role of Vata in pathophysiology and in prevalence of the disease. For this purpose in Group 2; Pramehaghna vati: (Vijaya sara, Jambu beeja, Arjuna, Vitkhadira, Amalaki, Methibeeja, Tejapatra each in equal part) and Pramehaghna Basti: (kwatha dravyas: Vijaya sara, Jambu beeja, Arjuna, Vitkhadira ; kalka dravya: Amalaki, Methibeeja, Tejapatra; sneha: boiled & then cooled Tila taila; honey, rock salt) were selected. The patients treated with Pramehaghna ghanavati had shown highly significant reduction in fasting blood sugar level while Basti group had shown significant reduction. Both the subgroups had shown highly significant reduction in postprandial blood sugar level but percentage reduction was more in Basti group.  

Key words: Prameha; Shodhana; Diabetes Mellitus; Basti; Virechana.