Obesity is a medical condition in which excess body fat has been accumulated in different parts in the body mainly in the subcutaneous tissues. It has an adverse effect on health and leads to reduced life expectancy as well as increased health problems. The world Health Organization has identified obesity as a global epidemic. The term “Sthaulya” is described in Ayurveda for “Over weight and Obesity”. This study was undertaken to identify the efficacy of Navaka Guggulu and Amritadya Guggulu which are mentioned in Bhaishajya Ratnawali in the treatment of Medoroga. Thirty overweight and obese patients were selected from Gampaha Wickramarachchi Ayurveda Teaching Hospital, Sri Lanka and randomly divided into two groups. Group A was treated with Navaka Guggulu and Group B with Amritadya Guggulu, 1g twice a day for a period of two months. Navaka Guggulu reduced mean body weight, abdomen circumference, mid-thigh circumference and mid arm circumference and mean BMI in statistically highly significant manner (p<0.001).  Amritadya Guggulu reduced mean body weight, abdomen circumference, mid-thigh circumference and mid arm circumference and mean BMI in statistically highly significant manner (p<0.001).  The improvement in excessive thirst, drowsiness, digestive capacity were statically highly significant (p<0.001). Finally, it could be concluded that both the drugs have more or less similar effect in improving some subjective and objective parameters of overweight and obesity.

Key words: Sthaulya; Navaka guggulu; Amritadya guggulu; Obesity.