The global obesity epidemic is highlighting its extensive health implications and economic costs. It notes that over 1. 4 billion adults were classified as overweight by the World Health Organization in 2014 to till now, with rates tripling since 1975. Obesity is linked to numerous chronic diseases, including Type 2 Diabetes and cardiovascular issues, and disproportionately affects women and socioeconomically disadvantaged groups. The text emphasizes the role of pancreatic lipase in fat metabolism and its significance as a drug target for obesity treatment. It reviews existing medications like Orlistat that inhibit this enzyme, thereby reducing fat absorption. Furthermore, it explores the potential of medicinal plants and their endophytic fungi derivatives in developing alternative treatments for obesity, underscoring their ability to produce bioactive compounds with therapeutic effects. The document also outlines various challenges in researching endophytic fungi and their lipase inhibitory activities, suggesting that these microorganisms could be valuable resources for new obesity treatments. It concludes by discussing the need for further studies to explore the diversity and capabilities of endophytic fungi in producing lipase inhibitors