Norepinephrine (NE) is commonly recommended as a first-line vasopressor treatment for the majority of adult patients with acute circulatory failure. Critically ill patients with circulatory shock may need rescue treatment with high doses of NE, which can be associated with a poor outcome due to excessive vasoconstriction. Herein we present a patient of post partum hypovolemic shock who developed gangrenous changes in the digits of her hands after norepinephrine administration.