Drug administration with transdermal patches is a non-invasive technique. It is an adhesive patch that is intended to penetrate the skin and enter the bloodstream, distributing a precise dosage of medication throughout the body. Compared to other administration methods, transdermal medication delivery is less intrusive, more patient-friendly, and able to avoid first-pass metabolism and the harmful acidic environment of the stomach that arises from oral drug absorption. Transdermal patches have garnered interest and been used for many years to treat a variety of illnesses and ailments. These medications include nitroglycerin, clonidine, nicotine, and fentanyl. This approach has also been investigated recently for the delivery of biologics in several applications. Here, we examine the body of research on the design