Cyclic application of “negative pressure” results in a superior local enhancement of cutaneous microcirculation with regards to blood flow and consecutive tissue oxygenation. Beyond that, repeated alterations between different levels of “negative pressure” due to cyclic application represent a greater stimulus for remote conditioning effects, indicating a superior local interaction with the underlying tissue. Here we showed the beneficial effect of cyclic Negative Pressure wound Therapy (NPWT) on donor site after skin graft.

Keywords: Skin Graft Donor Site; Cyclic Negative Pressure Wound Therapy.