Background: Chronic nonhealing ulcers (CNU) are a major health problem worldwide and it is a challenge for treating doctors. The role of Platelet Rich Plasma (PRP) in wound healing is a boon for the patients. PRP introduces the growth factors directly into the wound and fastened healing. Aims: to evaluate the efficacy and safety of PRP in CNU of various etiologies. Materials and Methods: It was prospective interventioal study including 47 patients with 59 CNU of various etiologies. PRP was prepared by manual double spin method and injected into the ulcer. Same procedure was repeated every two week until complete re-epithelization or up to 6 sittings whichever occurred earlier and followed-up after one month. The patients were evaluated for response and adverse events. The ulcer dimensions were measured and photographs were taken before treatment and at every subsequent sitting. Statistical analysis used: mean, standard deviation, z-test Results: The mean age of the patients was 42.11(SD 9.44) years. The mean duration of ulcer was 4.05 months (SD 2.08). The mean duration of healing was 4.9 weeks (SD 2.21). The mean percentage improvement in area and volume of the ulcers was 93.77% (SD 14.27) and 96.83% (SD 7.94) respectively. No adverse events were noted. Conclusion: Conventional therapies can’t provide growth factors which are necessary for the healing process.so, satisfactory healing does not occur in CNU. PRP fastened the healing by increasing rate of induction of granulation tissue without any significant adverse events. It is safe, biocompatible, cost effective, simple office-based procedure.

Keywords: Platelet rich plasma; Chronic non-healing ulcer; Wound.