The aim is to study the incidence of congenital anomalies in Government Rajaji hospital attached to Madurai Medical College, Madurai. Among the 3288 births during October 2016 to January 2017, there were 74 babies with congenital anomalies, among these 19 babies had neural tube defects. Results were analysed & compared with other studiesreported in the literature. Overall incidence of congenital anomalies 2.25% and theincidence of CNS anomalies was 33.7%. The incidence of neural tube anomalies was 0.57%

Keywords: Neural Tube Defects; Anencephaly; Spina Bifida; Hydrocephalus.