Cancer of uterine cervix is the most common cancer in women in developing world. 80% of the cases of cancer cervix occur in the developing countries and India accounts for 18% of them. High risk factors like teenage pregnancy, multiparity, low socioeconomic status are responsible for high incidence of invasive cancer (20 -45/1, 00,000 women) in our country. Unfortunately cases are diagnosed in the late stages and no curative treatment is possible, leading to a high mortality rate. To reduce mortality it is essential to diagnose these cases early. Objective: To evaluate the role of colposcopy in screening lesions of uterine cervix. Study Design: Prospective study Method: Fifty patients undergoing routine cervical cytologic screening in Father Muller Medical College at the department of Obs & Gynae outpatient clinic were randomly selected. All patients were evaluated by Pap smear, colposcopy and cervical punch biopsy. Pap smears and biopsies specimens were interpreted independently. Results: Of the 50 women, the cytology was found normal, inflammatory, ASCUS, LSIL, HSIL and squamous neoplasia in 6 (12%), 2(42%), 3(6%), 2(4%), 11 (22%), 3 (6%) respectively. Colposcopically guided cervical biopsy was found normal, inflammatory, CIN1, CIN2, CIN3, CIS, Squamous neoplasia in 8 (16%), 28(56%), 5(10%), 2(4%), 1(2%), 4(8%), 2(4%) respectively. Conclusion: Colposcopy followed by colposcopic guided cervical biopsy is a much sensitive method compared to cytology, especially in the high grade lesions of cervix and plays an important role in the down staging of cervical cancer.