Introduction: Coronary artery disease is a leading cause of mortality among postmenopausal women in our country. It has been recognized that women are protected from CAD prior to the menopause. Statistics have showed that 4% of more deaths are arising from cardiovascular disease among 70 years of age. The
most common cause of CVD is the development of atherosclerosis. This condition is multifactorial in origin, but dyslipidemia has been identified as a major risk factor. Dyslipidemia is one of the important modifiable risk factor in CHD. Objectives: To study the prevalence of dyslipidemia and type of lipid abnormalities
in postmenopausal women with acute myocardial infarction. Methods: Around 50 postmenopausal women above the age of 45 years admitted in ICCU for acute MI under Khaja Banda Nawaz Teaching and General Hospital have been studied over a period of 3years. The patients below the age of 45 years and those who had associated diabetes mellitus, hypertension, 3smoking; congenital hyperlipidemias have been excluded from the study. After a detailed history and thorough clinical examination routine investigations were done. Other investigations like ECG, serum cardiac markers such as CPK-MB, LDH, SGOT and 2-D Echo was done to diagnose MI. A special attention was paid to lipid profile to study the dyslipidemia pattern. Results: Out of 50 patients, 54% were between 51-60 years of age.68% were above 10 years of postmenopausal women. Chest pain was the predominant symptom in 90% of cases followed by profuse sweating and restlessness.30% of patients were admitted within 6 hours after the onset of symptoms and 40% of patients admitted 6-12 hours after the onset of symptoms. 62% had STEMI as presentation in ECG. Dyslipidemia was observed in 38 patients,of themincreased LDL levels and triglyceridemia was predominantly observed. Hypercholesterolemia was observed in 60% of patients in study group. LVF was the most common complication. The mortality rate was 20%. Conclusion: Dyslipidemia was observed in most of thepostmenopausal women, in that increased LDL levels and triglyceridemia was the most predominant one. The mortality rate was high with dyslipidemia group to normal lipids group of patients. So life style modifications and early initiation of statin therapy in postmenopausal women would increase the cardiovascular benefits