Objective: Application of Integrative Weaning Index in predicting weaning success. Materials and Methods: A prospective study on the mechanically ventilated 26 patients; after minimum 24 hours of ventilation criterias of readiness for weaning were recorded; those who met criteria were given 2 hour spontaneous breathing trial and Integrative Weaning Index (IWI) was calculated; those who tolerated the trial were immediately extubated; outcome was measured by the ability to maintain spontaneous, unassisted breathing for more than 48 hours aftet extubation. Results:IWI has high sensitivity (93%) and good negative predictive value of 75% Conclusion: Extubation using criteria of readiness for weaning and IWI >25 has good success rate of extubation with lower reintubation rate.