A correlational study was carried out to assess the correlation between post stroke cognitive impairment (PSCI) and activities of daily living (ADL) among patients with stroke admitted in a selected multi-specialty hospital in Kerala. 30 stroke patients were selected as sample by non probability purposive sampling method. The tools used for the study were structured interview schedule, Mini Mental Status Examination (MMSE), Modified Barthel Index (MBI) and National Institute of Health Stroke Scale (NIHSS). Data were collected from subjects at three different time points: on admission to the hospital (first phase assessment), one week after admission to hospital (second phase assessment) and on first follow up (third phase assessment). The study found that there was a significant negative correlation between PSCI and ADL of patients with stroke at different time points. The study also revealed that there was a significant change (decrease) in PSCI from first vs. second phase assessment and first vs. third phase assessment. The study also found a significant change (increase) in ADL of patients with stroke on repeated assessments.