Background: Haematological manifestations are the second commonest cause of morbidity and one of the common causes of mortality in HIV patients. In the course of ART administration, clinically significant haematologic abnormalities are common in persons with HIV infection. Objectives: To study the comparison of haematological parameters in subjects with different CD4 counts, to compare haematological findings of pre-ART group with ART group and two ART regimens namely ZLN and TLE. Study Design: Prospective observational study. Material and Methods: After obtaining informed consent, 225 PLHIV were clinically evaluated and subjected to CBC, PBS, ALC, ESR and CD4 count. Statistical Analysis: Data was expressed as percentage and mean ± standard deviation. Statistical tests used were chi-square test, Fisher’s exact test and Mann-Whitney U test and Kolmogorov-smirnov analysis. Results: TLC (p=0.02), MCV (p=0.04) and ALC (p<0.0003) were significantly raised while Hb, MCH, MCHC, PCV, ESR, CD4 count showed Non significant raised values in ART group in comparison to pre-ART group. MCH (p=0.01) and ALC (p<0.001) were significantly raised and Hb, MCHC, PCV, ESR, ALC showed Non significant raised values in PLHIV on TLE regimen when compared to ZLN regimen while TLC (p=0.04) was significantly raised in ZLN regimen. Conclusion: Most significant parameter was ALC in comparison between treated and untreated PLHIV groups and two ART regimens. TLE regimen fared better than ZLN regimen in treatment of PLHIV.

Keywords: Haematological; PLHIV; TLE; ZLN.