Bone mineral density (BMD) and grip strength (GS) are two commonly employed clinical orthopedic examination procedures, where the former is laboratory-based and the latter clinically performed. The aim of this review article was to update the evidence for inter-relationship between BMD and GS through a preliminary search of PubMed.Of the total 11 studies, there were six population-specific studies on normal healthy population (adolescents, adults, men, women, older adults, older women), two studies on healthy athletes (young athletes, combat athletes), and three studies on postmenopausal women (Japanese, Thai, Turkish). Whilst the question of site-specific or systemic still remains unanswered, the answer was reported to be influenced by many other variables such as gender, body weight, hand dominance and menopausal status. Albeit, there is a positive association and strong correlation existing between grip strength and bone mineral density, with grip strength being an independent predictor of BMD in some population. There is need for controlled clinical trials on interventions aimed at improving grip strength and their effects on BMD in osteoporotic men and women.