Abstract It is often argued that a blend of personality characteristics is known to affect the immune system. It has been identified that The Limbic Hypothalamic Pituitary Adrenal (LHPA) axis acts as the principal path of the communication between the immune system and the central nervous system. so this study was done to find out the relationship between Big Five personality traits and Total Peripheral Lymphocyte Count (TPLC) as a parameter of immunity in an undergraduate medical students (n=150). We calculated the correlation between personality variables and Total Peripheral Lymphocyte Count (TPLC). Further regression analyses were performed using personality variables as predictors and Total Peripheral Lymphocyte Count (TPLC) as criteria by using various statistical measures.
The results demonstrated that the Agreeableness and the Conscientiousness are the strongest predictors of lymphocyte count of all the personality traits. The results offer support for the hypothesis that stressed the essential links between personality and immune regulation.
Keywords: Big five; Personality Traits; Total Peripheral Lymphocyte Count (TPLC); Medical Students.