AbstractAmputations are caused by trauma, diabetic foot infection, and gas gangrene. A multidisciplinary team has effectively adapted advanced reconstructive techniques merged with regenerative medicine modalities to improve outcomes of nonhealing amputated stumps. These treatments combine traditional reconstruction measures with regenerative medicine applications and have been termed the ‘Hybrid reconstruction ladder’. This review article gives an overview of the hybrid reconstruction ladder in the management of nonhealing ulcers in the amputated stump.