Background: This study was designed to evaluate the effectiveness of clinical pharmacist intervention in lifestyle modification to improve glycemic control and diabetic peripheral neuropathic (DNP) symptoms in type 2 diabetic patients. Methods: Onehundred diabetic peripheral neuropathic patients were randomly assigned into two groups, intervention and usual care group. The intervention group has received the three month’s lifestyle modification program by a clinical pharmacist. The usual care group was provided with standard medical services. Lifestyle modification was assessed by using summary of diabetes selfcare activity (SDSCA) scale while the Morisky scale was used to assess medication adherence. Douleur Neuropathique 4 (DN4), Neuropathic Pain Scale (NPS), and Brief Pain Inventory (BPI) were used to assess diabetic peripheral neuropathy. Results: Intervented patients had significant positive effects of selfmanagement education on selfreported dietary habits, physical activity and foot care. The percentage of patients scoring moderate and high adherence scores in the intervention group were 40.7% and 14.8% respectively after three months follow up. After lifestyle modification, significant reduction in the percent of response of patients feeling electric shock, tingling, and pin needle were observed in the intervention patients. Lifestyle modification significantly improved all assessed pain qualities, except of feeling cold to a greater extent than the usual care group. Significant reductions in pain interference were observed in intervention group after the three months of follow up. Conclusion: The provision of lifestyle modification has positive effects on glycemic control and clinically effective approach for patients with DPN that improves severity in peripheral neuropathic symptoms and pain interference.

Keywords: Diabetic Peripheral Neuropathy; Clinical Pharmacist; Lifestyle Modification.