Assessment of veterinary vaccine safety is often done by veterinarians in animal houses in biological units using conventional methods which is a basically a complex and time consuming. In today’s era of Smart phones, tablet PCs and Netbooks where a spreadsheet program in the form of Excel is readily accessible by most veterinarians, it should be possible to adapt the various laborious steps involved in the said method to a spreadsheet program. In this article we have designed a spreadsheet program based on the steps involved in conventional method for assessment of vaccine safety.