50 children (30 males and 20 females) aged between 6 to 10 years suffering from nocturnal enuresis were studied. Clinical manifestation were 8 (16%) had frequency of micturation, 9 (18%) had urgency of micturation, 9 (18%) had twice or thrice in a week bed wetting 11 (22%) had daily bed wetting 5(10%) had pain while passing urine 4 (8%) had abdominal straining during micturation, 6 (12%) had bed wetting only in specific situation. Co-morbidities in nocturnal enuresis children were, 4 (8%) had constipation/soiling, 7 (14%) had poor attention in school, 3 (6%) had learning difficulty, 5 (10%) had complexity behavior 6 (12%) had UTI 4 (8%) had over activity of detrusor muscle 3 (6%) had neurogenic bladder 2 (4%) had congenital anomalies. Comparison of efficacy of pharmacological and non pharmacological trials and results shown that, dry bed training 60% response and 40% relapse In alarm 55% had response and 10-45% had relapse. In the motivation therapy. 20% had response and 3% had relapse, In the treatment of Desmopressin response was 50-55% and 40-45% was relapse. In Imiprine administration, 30- 50% was response, and 70-90% was relapse In oxybutyrins 35.60% response trial and result and 40% was relapse. This practical study to treat the nocturnal enuresis will be quite useful for pediatrician, psychiatrist and urologist to evaluate the etiology and treat the patients efficiently.

Keywords: Nocturnal; Emotional; Behavior; Pharmacologic; Bed Wetting