Three breeds of cows namely, non descriptive (ND), Red Sindhi (RS) and cross breed Jersey (CBJ) cow, and each having three different age groups (2 years, 6 years and 10 years) were used in this study. Since the reports on the hematological profile with respect to these breeds and age are inadequate, the present study is undertaken. Among the three breeds, the highest (14.36±0.02g/dl) and the lowest (8.51±0.04g/dl) mean hemoglobin concentration were recorded in 2 years CBJ and 10 years ND cow respectively. The highest average total erythrocytes count (11.01±0.06 x106) and PCV (51.16±0.60%) were recorded in 6 years ND and 2 years CBJ cow respectively while the lowest value of total erythrocyte count (4.89±0.13 x 106) and PCV (26.56±0.21%)  were recorded in 2 years and 10 years ND cow respectively. The highest average MCH (22.61±0.62pg) and MCV (71.94±2.11fl) were observed in 2 years ND whereas the lowest average MCH (10.77±0.04pg) and MCV (34.08±0.04fl) were noted in 6 years ND cow. The highest MCHC (32.88±0.22%) and the lowest (28.02±0.33%) were recorded in 2 years RS and 2 years CBJ cow respectively. The highest and the lowest total leukocyte count were recorded in 2 years ND and 6 years RS cow respectively. The significant difference at p<0.05 and p<0.01 was found among the different age groups of breeds for all the hematological parameters and no significant difference was found for eosinophil and basophil count. The difference may be due to differences in age, breed and physiological status.

Keywords: ND Cow; RS Cow; CBJ Cow.