The purpose of the study was to compare the clinical efficacy of tetracycline impregnated fibrillar collagen in conjunction with scaling and root planing to scaling and root planing alone in the treatment of chronic periodontitis. The study was conducted in a split mouth design. Thirty five patients having at least two non adjacent sites in different quadrants with periodontal pockets e” 5mm and with bleeding on probing at initial visit were treated with both scaling and root planing plus tetracycline fibers or with either scaling and root planing alone. Baseline and follow up measurements included plaque index, gingival index, probing pocket depth and clinical attachment level. Both treatment modalities were affective in improving clinical parameters over three months observation period. The combined antimicrobial and mechanical debridement therapy has shown better results as compared to scaling and root planing alone. Application of tetracycline in modified collagen matrix following scaling and root planing might be beneficial in treatment of chronic adult periodontitis and improving periodontal parameters for 3 months duration.