Objective: The aim of the present study is to compare the effectiveness of intravenously administered Granisetron Metoclopramide and Droperidol in the prevention of postoperative nausea and vomiting in patients undergoing gynaecological Diagnostic laparoscopy under general anaesthesia. Design: The antiemetic efficacy of granisetron, and metoclopramide was assessed in postoperative nausea and vomiting for a period of 24 hours. Duration: December 2016 to November 2017. Setting: Department of Anesthesia, Bhaskar Medical College, Ranga Reddy, Telangana. Participants: A total number of 75 female cases between the age group of 18–35 years belonging to ASA grade I and ASA grade II with primary infertility coming for gynecological diagnostic laparoscopy. Methods: Patients were divided into 3 groups of 25 each. Group A received intravenous granisetron (40mcg/kg), Group B received Metoclopramide (0.2mg/kg) and Group C received droperidol (25mcg/kg) prophylactically for prevention of postoperative nausea and vomiting. The primary end point was the occurrence of PONV. The main outcomes were monitored for study period of 24hours postoperatively. Postoperatively the patients were observed in postoperative ward for 24hours for postoperative nausea, retching and vomiting, headache, sedation, dizziness, allergic reactions, extra pyramidal symptoms. Nausea and vomiting were evaluated on three point ordinal scale (0 = none, 1= nausea, 2 = vomiting/retching), with no distinction between vomiting and retching (i.e. retching was considered a vomiting event). Results: In the early postoperative period (0­4hrs), the incidence of nausea & vomiting was effectively controlled with use of granisetron & droperidol, it was significantly higher in metoclopramide group. In the late postoperative period (4­24hrs), PONV was significantly lower with granisetron and droperidol when compared to metoclopromide (p value <= 0.001). Conclusion: Administration of granisetron preoperatively is superior to metoclopramide and droperidol in long term prevention of PONV following gynecological diagnostic laparoscopy.